When triglycerides 
climb too high.

Severe Hypertriglyceridemia (sHTG) is a condition in which triglyceride levels reach 500 mg/dL or higher. Understanding your numbers is the first step toward lower risk and better health.

what you’ll find on this page

Defining sHTG

Fasting triglycerides at or above 500 mg/dL are considered severe. Levels at or above 1,000 mg/dL are very severe and sharply raise the risk of pancreatitis.

Why it happens

sHTG is usually driven by a mix of genetic, medical, and lifestyle factors, including diabetes, kidney disease, certain medications, alcohol, and diet.

Why it matters

Very high triglycerides can lead to acute pancreatitis, cardiovascular disease, fatty liver, and worsening metabolic health.

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